The Interaction of Tuberculosis and HIV in Africa

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HIV infection affects 34 million of the world population and Tuberculosis (TB) affects 15 million. The greatest burden of both diseases is in sub Saharan Africa [1]. In high HIV prevalence countries in sub Saharan Africa TB notifications have increased over 20 years from 1990 to 2009 [2]. According to the WHO world report in 2009, HIV associated TB cases accounted for 78% of the total cases in Africa yet in South East Asia it was only 13% [3]. Clearly high HIV prevalence rates are associated with high TB prevalence rates, to the extent that HIV infected people are 20 to 30 times likely to develop TB [4]. In addition, HIV-associated TB contributes disproportionately to TBrelated deaths. In 2008, there was 37% estimated case fatality due to TB among HIV infected people while HIV uninfected accounted for 16% [3]. The probable reasons for such high case fatality rates include rapid progression of disease in HIV infected individuals and, delayed diagnosis of both HIV and TB. There is also a delay in accessing combination antiretroviral therapy and higher rates of multidrug resistant TB in HIV infected patients