Patients infected with HIV typically seroconvert within weeks of primary HIV infection. In rare cases, patient do not develops antibodies despite demonstrable HIV infection by p24 antigen or viral load assays; a seronegative HIV. Very few such cases been reported so far in the literature [1-11]. Seronegative HIV is many times difficult to differentiate from acute seroconversion illness due to HIV in clinical practice. Here we are describing such case with clinical dilemma.