MS is a chronic progressive autoimmune disease of central nervous system, which leads to neurological impairment and permanent clinical disability. There are effective treatments available for the most common form of MS, relapsing-remitting MS, but there are no efficacious therapies for progressive forms of MS. Several patients also need to discontinue their treatment due to adverse events. Researchers have discovered that a folate receptor is expressed on phagocytosing cells, which will eat the targets identified as foreign substances. In autoimmune diseases this identification process is impaired and the immune cells start to target body's own tissue. Therefore, folate receptor can be used to guide the effect of a drug to achieve better treatment responses.

The Swiss pharmaceutical company owned Endocyte, has previously developed a folate-targeted aminopterin therapy, which targets folate receptors on phagocytosing cells. This treatment has shown to shut down active inflammation in multiple disease models, but this study was the first to demonstrate efficacy in a chronic progressive model of MS induced by intra-cerebral injection in rats. The efficacy was apparent during chronic phase of the disease when the inflammatory activity and the size of lesion were significantly reduced, says researcher Petri Elo.

Regards

John
Editorial Assistant
Immunogenetics Open Access