Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high-quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive.

Thyroxine is absorbed from the gastro-intestinal tract, although its absorption is variable. In the plasma, it is extensively bound to plasma proteins, mostly to thyroid-binding globulin but also to albumin and pre-albumin. There are numerous ways that it is metabolized, including 5'-deiodination (to produce the active T₃), 5-deiodination (producing inactive rT₃), deamination, decarboxylation, and ether bond cleavage. It may also be conjugated via the hydroxyl group to form sulfates or glucuronides Hernandez and St Germain (1997). The liver is a major site of metabolism, although deiodination to T3 probably occurs in most tissues. In the presence of normal thyroid function, the plasma half-life of thyroxine is about 6–7 days, this being prolonged in hypothyroidism and shortened in hyperthyroidism.

A thyroxine test helps diagnose disorders of the thyroid. The thyroid is a small, butterfly-shaped gland located near the throat. Your thyroid makes hormones that regulate the way your body uses energy. It also plays an important role in regulating your weight, body temperature, muscle strength, and even your mood. Thyroxine, also known as T4, is a type of thyroid hormone. This test measures the level of T4 in your blood. Too much or too little T4 can indicate thyroid disease.

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Denise Williams
Editorial Manager     
Journal of Thyroid Disorders & Therapy
E-mail id: thyroiddisorders@longdomjournal.org