Immune Response in Neurological Disorders

Recent developments in the investigation of neurological disorders led to an enhanced focus on the role of the immune response in diseases of the nervous system. It is now known that there is a close interaction of the peripheral and central immune system with the nervous system and that disorders such as Alzheimer’s disease, Multiple Sclerosis, Parkinson’s disease, chronic neuropathic pain, or stroke are greatly impacted by immunity. Besides being purely a response to neurodegeneration, immune networks seem to play a major role in processes such as synaptic alterations, apoptotic signaling, pain perception, sickness behavior, and depression typically associated with neurological diseases. Next to the role of the immune system for disease development and maintenance, the role of immune responses for tissue regeneration and cell survival has drawn the attention of many researchers recently. More profound knowledge of the underlying mechanisms of immune-mediated tissue regeneration might ultimately lead to the development of novel strategies to suppress pathological immune responses and to promote regeneration of the nervous system in the aforementioned diseases.

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Stella M
Journal Manager
Immunome Research
Email: immunome@immunologyjournals.org
https://www.longdom.org/immunome-research.html