The vestibular system is a sensory system which plays a critical role in balance. We developed a damage protocol to selectively target type I vestibular hair cells.This novel protocol uses a timed transtympanic administration of gentamicin. Uniform damage to vestibular function and hair cell loss were achieved.This damage protocol can be used for research into vestibular balance disorders. type I hair cells in a way that produces consistent and predictable lesions that can be used for reliable inter-animal and inter-group comparison in balance research. This objective is achieved by transtympanic injection of gentamicin on both the round window membrane and oval window over a fixed time period followed by thorough washing.

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Sandra Jones

Journal Manager

Hair Therapy and Transplantation

Email: hairtherapy@emedscholar.com