Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines and secretory immunoglobulin (SIgA). Therefore, in this study, we investigated the levels of specific-SIgA for SARS-CoV-2 and cytokines in the airways mucosa 37 patients who were suspected of COVID-19. According to the RT-PCR results, the patients were separated into three groups: negative for COVID-19 and other viruses (NEGS, n=5); negative for COVID-19 but positive for the presence of other viruses (OTHERS, n=5); and the positive for COVID-19 (COVID-19, n=27). Higher specific-SIgA for SARS-CoV-2, IFN-β, and IFN-γ were found in the COVID-19 group than in the other groups. Increased IL-12p70 levels were observed in OTHERS group as compared to COVID-19 group. When the COVID-19 group was sub stratified according to the illness severity, significant differences and correlations were found for the same parameters described above comparing severe COVID-19 to the mild COVID-19 group and other non-COVID-19 groups. For the first time, significant differences are shown in the airway’s mucosa immune responses in different groups of patients with or without respiratory SARS-CoV-2 infection.

Medical and surgical pathology (NLM ID: 101689989) deals with the macroscopic and microscopic examination of surgical specimens for effective diagnosis of disease. Surgical specimens are of two categories, biopsies, and surgical resections. Surgical pathology also includes subdivisions such as dermatopathology, cytopathology, hematopathology, neuropathology and pediatric pathology.

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Thank you, and Regards,
John Robert
Journal of Medical and Surgical Pathology
ISSN: 2472-4971 | NLM ID: 101245791