Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high-quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive.

Hypothyroidism (underactive thyroid) is a condition in which your thyroid gland doesn't produce enough of certain crucial hormones. Hypothyroidism may not cause noticeable symptoms in the early stages.

Although treatment guidelines specify levothyroxine as the standard of care for hypothyroidism, many thyroid specialists acknowledge a dirty little not-so-secret: When pressed by an insistent patient, many clinicians find it prudent to explore a trial of T4 and T3 combination therapy. And now some experts are saying new evidence is making them take another look at combination therapy. Bianco notes that monotherapy with T4 does not restore circulating T3 levels, which provides a rationale for combination therapy. There is also evidence - not from clinical trials -that a subset of hypothyroid patients could benefit from combination treatment. A recently discovered genetic polymorphism that occurs in some 16% of the population of the United Kingdom interferes with metabolism of T4 to T3. The polymorphism has been replicated in a mouse model to generate a form of hypothyroidism that can be corrected with administration of T3.

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Regards
Denise Williams
Editorial Manager     
Journal of Thyroid Disorders & Therapy
E-mail id: thyroiddisorders@longdomjournal.org